Publications

Santini-Oliveira, Marília, et al. "Development of the Sm14/GLA-SE Schistosomiasis Vaccine Candidate: An Open, Non-Placebo-Controlled, Standardized-Dose Immunization Phase Ib Clinical Trial Targeting Healthy Young Women." Vaccines 10.10 (2022): 1724.

2022

Santini-Oliveira, Marilia, et al. "Schistosomiasis vaccine candidate Sm14/GLA-SE: Phase 1 safety and immunogenicity clinical trial in healthy, male adults." Vaccine 34.4 (2016): 586-594.

2016

Tendler, Miriam, Marilia Almeida, and Andrew Simpson. "Development of the Brazilian anti schistosomiasis vaccine based on the recombinant fatty acid binding protein Sm14 plus GLA-SE adjuvant." Frontiers in immunology 6 (2015): 218.

2015

Kupferschmidt, Kai. "A worm vaccine, coming at a snail's pace." (2013): 502-503.

2013

Henrique, CH., et al. "Segurança clínica do Antígeno Recombinante Sm14 em bovinos." A Hora Veterinária 32.188 (2012): 40-43.

2012

Mendes, Ricardo E., et al. "Evaluation of local immune response to Fasciola hepatica experimental infection in the liver and hepatic lymph nodes of goats immunized with Sm14 vaccine antigen." Memórias do Instituto Oswaldo Cruz 105 (2010): 698-705.

2010

Ramos, Celso RR, et al. "Stability improvement of the fatty acid binding protein Sm14 from S. mansoni by Cys replacement: structural and functional characterization of a vaccine candidate." Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1794.4 (2009): 655-662.

2009

Tendler, Miriam, and Andrew JG Simpson. "The biotechnology-value chain: development of Sm14 as a schistosomiasis vaccine." Acta tropica 108.2-3 (2008): 263-266.

2008

Varaldo, Paula B., et al. "Mycobacterial codon optimization of the gene encoding the Sm14 antigen of Schistosoma mansoni in recombinant Mycobacterium bovis Bacille Calmette-Guerin enhances protein expression but not protection against cercarial challenge in mice." FEMS Immunology & Medical Microbiology 48.1 (2006): 132-139.

2006

Varaldo, Paula B., et al. "Recombinant Mycobacterium bovis BCG expressing the Sm14 antigen of Schistosoma mansoni protects mice from cercarial challenge." Infection and immunity 72.6 (2004): 3336-3343.

2004

Abreu, Patrícia AE, et al. "Sm14 of Schistosoma mansoni in fusion with tetanus toxin fragment C induces immunoprotection against tetanus and schistosomiasis in mice." Infection and immunity 72.10 (2004): 5931-5937.

2004

Pertinhez, Thelma A., et al. "1H, 15N and 13C resonance assignments of the apo Sm14-M20 (C62V) protein, a mutant of Schistosoma mansoni Sm14." Journal of Biomolecular NMR 29.4 (2004): 553-554.

2004

Vilar, Mônica Magno, et al. "An experimental bivalent peptide vaccine against schistosomiasis and fascioliasis." Vaccine 22.1 (2003): 137-144.

2003

Ramos, Celso Raul Romero, et al. "Gene Structure and M20T Polymorphism of the Schistosoma mansoni Sm14 Fatty Acid-binding Protein: MOLECULAR, FUNCTIONAL, AND IMMUNOPROTECTION ANALYSIS." Journal of Biological Chemistry 278.15 (2003): 12745-12751.

2003

Thaumaturgo, Nilton, et al. "Characterization of Sm14 related components in different helminths by sodium dodecyl sulphate-polyacrylamide gel electrophoresis and Western blotting analysis." Memórias do Instituto Oswaldo Cruz 97 (2002): 115-116.

2002

Thaumaturgo, Nilton, et al. "Preliminary analysis of Sm14 in distinct fractions of Schistosoma mansoni adult worm extract." Memórias do Instituto Oswaldo Cruz 96 (2001): 79-83.

2001

Tendler, Miriam, et al. "A Schistosoma mansoni fatty acid-binding protein, Sm14, is the potential basis of a dual-purpose anti-helminth vaccine." Proceedings of the National Academy of Sciences 93.1 (1996): 269-273.

1996

Tendler, Miriam, et al. "Vaccination in murine schistosomiasis with adult worm derived antigens-II. Protective and immune response in inbred mice." Memórias do Instituto Oswaldo Cruz 87 (1992): 281-286.

1992

Tendler, Miriam, et al. "Schistosoma mansoni-New Zealand rabbit model: resistance induced by infection followed by active immunization with protective antigens." The Journal of parasitology (1991): 138-141.

1991

Moser, Doris, et al. "A 14-kDa Schistosoma mansoni polypeptide is homologous to a gene family of fatty acid binding proteins." Journal of Biological Chemistry 266.13 (1991): 8447-8454.

1991

Pinto, R. Magalhães, et al. "Autoradiographic analysis of Schistosoma mansoni migration in the NZ rabbit." Memórias do Instituto Oswaldo Cruz 85 (1990): 91-94.

1990

Almeida, Marilia SS, et al. "Curative and protective activity in rabbits after reinfection with Schistosoma mansoni: a new model of immunity?." The Journal of parasitology (1989): 308-310.

1989

Mendonça, M. C., and M. Tendler. "Localization of Schistosoma mansoni protective antigens by indirect immunofluorescence." Mem. Inst. Oswaldo Cruz (1987): 235-236.

1987

Pinto, R. Magalhães, et al. "Schistosoma mansoni: migration patterns in normal and immunized Swiss Webster mice, by means of autoradiographic analysis." Mem. Inst. Oswaldo Cruz (1987): 231-232.

1987

Almeida, Marília SS, et al. "Schistosoma mansoni-NZ rabbit-model: resistance due to infection and active immunization with adult worm antigen." Mem. Inst. Oswaldo Cruz (1987): 233-233.

1987

Tendler, Miriam. "Schistosoma mansoni: protective antigens." Memórias do Instituto Oswaldo Cruz 82 (1987): 125-128.

1987

Campos, D. G., et al. "Pesquisa simultânea de antígeno, anticorpo e imunocomplexos específicos no soro de pacientes com esquistossomose crônica." Memórias do Instituto Oswaldo Cruz 81 (1986): 135-144.

1986

Tendler, M., et al. "Acquired resistance of mice against S. mansoni and lung granulomatous reaction induced by BCG." Memórias do Instituto Oswaldo Cruz 78 (1983): 147-151.

1983

Tendler, M., et al. "Immunogenetic and protective activity of an extract of Schistosoma mansoni." Memórias do Instituto Oswaldo Cruz 77 (1982): 275-283.

1982

Tendler, Miriam, and Mauro Scapin. "Schistosoma mansoni antigenic extracts obtained by different extraction procedures." Memórias do Instituto Oswaldo Cruz 76 (1981): 103-109.

1981

Patents

Publications

Santini-Oliveira, Marília, et al. "Development of the Sm14/GLA-SE Schistosomiasis Vaccine Candidate: An Open, Non-Placebo-Controlled, Standardized-Dose Immunization Phase Ib Clinical Trial Targeting Healthy Young Women." Vaccines 10.10 (2022): 1724.

Santini-Oliveira, Marilia, et al. "Schistosomiasis vaccine candidate Sm14/GLA-SE: Phase 1 safety and immunogenicity clinical trial in healthy, male adults." Vaccine 34.4 (2016): 586-594.

Tendler, Miriam, Marilia Almeida, and Andrew Simpson. "Development of the Brazilian anti schistosomiasis vaccine based on the recombinant fatty acid binding protein Sm14 plus GLA-SE adjuvant." Frontiers in immunology 6 (2015): 218.

Kupferschmidt, Kai. "A worm vaccine, coming at a snail's pace." (2013): 502-503.

Henrique, CH., et al. "Segurança clínica do Antígeno Recombinante Sm14 em bovinos." A Hora Veterinária 32.188 (2012): 40-43.

Mendes, Ricardo E., et al. "Evaluation of local immune response to Fasciola hepatica experimental infection in the liver and hepatic lymph nodes of goats immunized with Sm14 vaccine antigen." Memórias do Instituto Oswaldo Cruz 105 (2010): 698-705.

Ramos, Celso RR, et al. "Stability improvement of the fatty acid binding protein Sm14 from S. mansoni by Cys replacement: structural and functional characterization of a vaccine candidate." Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1794.4 (2009): 655-662.

Tendler, Miriam, and Andrew JG Simpson. "The biotechnology-value chain: development of Sm14 as a schistosomiasis vaccine." Acta tropica 108.2-3 (2008): 263-266.

Varaldo, Paula B., et al. "Recombinant Mycobacterium bovis BCG expressing the Sm14 antigen of Schistosoma mansoni protects mice from cercarial challenge." Infection and immunity 72.6 (2004): 3336-3343.

Abreu, Patrícia AE, et al. "Sm14 of Schistosoma mansoni in fusion with tetanus toxin fragment C induces immunoprotection against tetanus and schistosomiasis in mice." Infection and immunity 72.10 (2004): 5931-5937.

Pertinhez, Thelma A., et al. "1H, 15N and 13C resonance assignments of the apo Sm14-M20 (C62V) protein, a mutant of Schistosoma mansoni Sm14." Journal of Biomolecular NMR 29.4 (2004): 553-554.

Vilar, Mônica Magno, et al. "An experimental bivalent peptide vaccine against schistosomiasis and fascioliasis." Vaccine 22.1 (2003): 137-144.

Ramos, Celso Raul Romero, et al. "Gene Structure and M20T Polymorphism of the Schistosoma mansoni Sm14 Fatty Acid-binding Protein: MOLECULAR, FUNCTIONAL, AND IMMUNOPROTECTION ANALYSIS." Journal of Biological Chemistry 278.15 (2003): 12745-12751.

Thaumaturgo, Nilton, et al. "Characterization of Sm14 related components in different helminths by sodium dodecyl sulphate-polyacrylamide gel electrophoresis and Western blotting analysis." Memórias do Instituto Oswaldo Cruz 97 (2002): 115-116.

Thaumaturgo, Nilton, et al. "Preliminary analysis of Sm14 in distinct fractions of Schistosoma mansoni adult worm extract." Memórias do Instituto Oswaldo Cruz 96 (2001): 79-83.

Tendler, Miriam, et al. "A Schistosoma mansoni fatty acid-binding protein, Sm14, is the potential basis of a dual-purpose anti-helminth vaccine." Proceedings of the National Academy of Sciences 93.1 (1996): 269-273.

Tendler, Miriam, et al. "Vaccination in murine schistosomiasis with adult worm derived antigens-II. Protective and immune response in inbred mice." Memórias do Instituto Oswaldo Cruz 87 (1992): 281-286.

Tendler, Miriam, et al. "Schistosoma mansoni-New Zealand rabbit model: resistance induced by infection followed by active immunization with protective antigens." The Journal of parasitology (1991): 138-141.

Moser, Doris, et al. "A 14-kDa Schistosoma mansoni polypeptide is homologous to a gene family of fatty acid binding proteins." Journal of Biological Chemistry 266.13 (1991): 8447-8454.

Pinto, R. Magalhães, et al. "Autoradiographic analysis of Schistosoma mansoni migration in the NZ rabbit." Memórias do Instituto Oswaldo Cruz 85 (1990): 91-94.

Almeida, Marilia SS, et al. "Curative and protective activity in rabbits after reinfection with Schistosoma mansoni: a new model of immunity?." The Journal of parasitology (1989): 308-310.

Mendonça, M. C., and M. Tendler. "Localization of Schistosoma mansoni protective antigens by indirect immunofluorescence." Mem. Inst. Oswaldo Cruz (1987): 235-236.

Pinto, R. Magalhães, et al. "Schistosoma mansoni: migration patterns in normal and immunized Swiss Webster mice, by means of autoradiographic analysis." Mem. Inst. Oswaldo Cruz (1987): 231-232.

Almeida, Marília SS, et al. "Schistosoma mansoni-NZ rabbit-model: resistance due to infection and active immunization with adult worm antigen." Mem. Inst. Oswaldo Cruz (1987): 233-233.

Tendler, Miriam. "Schistosoma mansoni: protective antigens." Memórias do Instituto Oswaldo Cruz 82 (1987): 125-128.

Campos, D. G., et al. "Pesquisa simultânea de antígeno, anticorpo e imunocomplexos específicos no soro de pacientes com esquistossomose crônica." Memórias do Instituto Oswaldo Cruz 81 (1986): 135-144.

Tendler, M., et al. "Acquired resistance of mice against S. mansoni and lung granulomatous reaction induced by BCG." Memórias do Instituto Oswaldo Cruz 78 (1983): 147-151.

Tendler, M., et al. "Immunogenetic and protective activity of an extract of Schistosoma mansoni." Memórias do Instituto Oswaldo Cruz 77 (1982): 275-283.

Tendler, Miriam, and Mauro Scapin. "Schistosoma mansoni antigenic extracts obtained by different extraction procedures." Memórias do Instituto Oswaldo Cruz 76 (1981): 103-109.

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